A
advanced bioactive ceramic biomaterials
biodegradable ceramic biomaterials,
187–209
development for tissue engineering,
188–91
advanced synthetic polymer biomaterials,
71–93
selection of reported poly(2-oxazoline)s structures that allow post-polymerisation modification,
77
poly(alkyl carbonate)s,
7–8
synthesis of poly(anhydride) using thiolene polymerisation,
82
poly(ester)s and poly(ester) block copolymers,
72–5
strategy for preparation of hetero-bifunctional poly(
ε-caprolactone),
75
carbonate monomers for ring opening polymerisation preparation of functional aliphatic polycarbonates,
79
first-generation amine poly(ethylene glycol) derivatives for amine conjugation,
80
fibre mats of synthetic anionic copolypeptide of L-glutamic acid and L-tyrosine produced by electrospinning,
81
aromatic chain extenders with varying spacer length,
85
AIGIS antibacterial envelope,
21
magnetite-containing alginate beads,
47
structures of alginate epimers,
45
amino-propyltriethoxysilane,
107
anhydrous calcium phosphate,
197–9
austenitic stainless steel,
122
B
Bifidobacterium breve,
48
bio-inert hard shell packaging,
12
biological responses to ionic dissolution products,
208
cytotoxicity of metallic biomaterials,
148–65
effect of load and wear on implant degradation,
150,
153–4
macrophage-mediated inflammatory events,
154–8
osteoclast-mediated bone resorption,
160–2
osteolysis as function of implant-associated mechanotransduction,
162–3
role of bacterial endotoxins in triggering particle-induced inflammatory response,
158–60
surface modification as means of enhancing biocompatibility and corrosion resistance,
163–5
biocompatible hard shell packaging,
12
biodegradable ceramic biomaterials
advanced bioactive ceramic biomaterials,
187–209
development for tissue engineering,
188–91
stability of Mg coating deposited by means of physical vapour deposition,
137
biofunctional polymers immobilisation,
164–5
bioinert ceramic biomaterials
fabrication techniques,
179–83
hardness, high compressive strength and wear resistance,
173–9
bioinert refractory polycrystalline compounds
microstructure of internal surface of alumina tubes,
175
hardness, high compressive strength and wear resistance,
173–9
surface crystallisation of leucite in SiO
2-Al
2O
3-K
2O-Na
2O glass,
179
tetragonal to monoclinic transformation increases fracture toughness,
177
advanced synthetic and hybrid polymer from inorganic and mixed organic-inorganic sources,
100–16
organic-inorganic hybrid polymers,
112–14
silicon-based inorganic polymers,
102–9
synthetic inorganic polymers,
101–2
advanced synthetic polymer biomaterials from organic sources,
71–93
poly(alkyl carbonate)s,
77
poly(ester)s and poly(ester) block copolymers,
72–5
current trends in design and fabrication,
22–3
development and realisation,
4–8
implantable device design,
1–23
device-associated infections,
19–22
implantable systems design,
8–19
C
calcium phosphate-based injectable bone cements,
192–3
calcium phosphate dehydrate,
196–7
anhydrous calcium phosphate,
197–9
resorption behaviour of monetite granules vs bovine hydroxyapatite,
198
calcium phosphate dehydrate,
196–7
differential morphologies of hydroxyapatite nano- and micro-crystals,
205
SEM image of crystalline octacalcium phosphate-coated titanium disc,
200
schematic of in vivo interactions with calcium phosphate ceramics,
195
tricalcium phosphate,
201–4
phase equilibrium diagram proposed to describe phase relationships,
202
cardiac electro-physiological mapping activities,
cell growth stimulation,
188
cellular-mediated inflammatory response,
150
chemical vapour deposition,
164
complex carrier structures,
43–5
derivatives and their potential as vehicles for targeted drug delivery,
40–3
layer-by-layer self-assembly of polyelectrolyte capsules incorporated with several functionalities,
44
amphiphilic chitosan derivatives for drug delivery,
41–2
chitosan-based tissue scaffolds,
37–9
complex carrier structures,
43–5
layer-by-layer self-assembly of polyelectrolyte capsules incorporated with several functionalities,
44
structure–property relationship of chitosan,
35
chitosan-collagen hydrogels,
37
chitosan-EDTA conjugates,
40
chitosan-sulfobutylether-
β-cyclodextrin nanoparticles,
40
cobalt-based alloys,
123–4
in vitro micro-vessel formation by endothelial cells on collagen-glycosaminoglycan scaffold,
49
computer-aided hard machining,
180,
182–3
corrosion resistance,
127
biocompatibility of metallic biomaterials,
148–65
effect of load and wear on implant degradation,
150,
153–4
macrophage-mediated inflammatory events,
154–8
osteoclast-mediated bone resorption,
160–2
osteolysis as function of implant-associated mechanotransduction,
162–3
role of bacterial endotoxins in triggering particle-induced inflammatory response,
158–60
surface modification as means of enhancing biocompatibility and corrosion resistance,
163–5
H
hexamethylene diisocyanate scaffolds,
90
host tissue chemical bonding,
188
hot isostatic pressing,
174,
181
hybrid polymer biomaterials
from inorganic and mixed organic-inorganic sources,
100–16
organic-inorganic hybrid polymers,
112–14
silicon-based inorganic polymers,
102–9
synthetic inorganic polymers,
101–2
hydrothermal treatment,
139–40
I
direct and indirect effects of wear particles,
154
biomaterials design,
1–23
current trends in biomaterials design and fabrication,
22–3
development and realisation,
4–8
device-associated infections,
19–22
in-hospital charges associated with cardiac implantable electrophysiological device infection,
20
implantable systems design,
8–19
Ashby diagram to identify ideal materials for electrically-active tissue-device interfaces,
14
complex implantable system,
10
device development and system requirements,
11–12
device encapsulation,
12–13
electrode material,
13–16
implantable electronics and their applications,
9–11
schematic presentation of set-up of glucose biofuel cell,
18
potential causes for implant failure,
in vitro fatigue testing,
126–7
indirect rapid prototyping,
192
inorganic mineral phase,
189
M
macrophage-mediated inflammatory events,
154–8
death of fibroblast cell in peri-implant space,
157
local neurotoxic effects of metal debris in cells,
155
macrophage toxicity,
156–8
martensitic stainless steel,
122
martensitic transformation,
130
cytotoxicity and biocompatibility,
148–65
effect of load and wear on implant degradation,
150,
153–4
macrophage-mediated inflammatory events,
154–8
osteoclast-mediated bone resorption,
160–2
osteolysis as function of implant-associated mechanotransduction,
162–3
role of bacterial endotoxins in triggering particle-induced inflammatory response,
158–60
surface modification as means of enhancing biocompatibility and corrosion resistance,
163–5
SEM images depicting enhanced antibacterial activity and biocompatibility,
123
Ti and Ti-based alloys,
124–8
influence of thermomechanical processing on development of various microstructures,
126
types and advanced applications,
121–40
noble metal alloys,
128–9
cytotoxicity biocompatibility of alloys,
149–50
systemic toxicity of small sized debris particles after hip replacement,
151–2
micro-electro-mechanical systems (MEMS),
micro-electrode impedance,
13
microfluidic lab-on-chip biomedical systems,
microwave-assisted curing,
108
microwave-assisted polymer fabrication,
92
minimal load-bearing metallic implants,
153–4
mono
-N-carboxymethyl chitosan,
40
N
N-carboxybutyl-chitosan,
37
N-trimethylated chitosan,
40
nanoporous oxide layers,
164
natural polymer biomaterials,
32–58
magnetite-containing alginate beads,
47
structures of alginate epimers,
45
chitin and chitosan,
34–45
amphiphilic chitosan derivatives for drug delivery,
41–2
chitin derivatives and their potential as vehicles for targeted drug delivery,
40–3
chitosan-based tissue scaffolds,
37–9
complex carrier structures,
43–5
layer-by-layer self-assembly of polyelectrolyte capsules incorporated with several functionalities,
44
structure–property relationship of chitosan,
35
in vitro micro-vessel formation by endothelial cells on collagen-glycosaminoglycan scaffold,
49
features and applications of chimeric protein-based biomaterials,
33
gelatine-based drug delivery vehicles,
50
gelatine tissue scaffolds and hydrogels,
50–2
varying interpore connectivity of 3-D nanofibrous gelatine scaffold,
51
immunocytes as ‘Trojan horses’ for molecule delivery,
57–8
tensile properties of silk polymeric fibres,
55
viral particles and bacteriophage capsids for drug delivery,
56–7
neurosurgical devices,
134
N, N-dimethylacetamide,
92
noble metal alloys,
128–9
O
organic-inorganic hybrid polymers,
112–14
metal-containing inorganic polymers,
113–14
synthetic organic polymeric materials,
112–13
osteoclast-mediated bone resorption,
160–2
wear debris triggers processes that lead to inflammation and osteolysis,
161
function of implant-associated mechanotransduction,
162–3
signal transduction and mechanotransduction events of adherent cell,
163
P
pathogen-associated molecular patterns (PAMPs),
159
peri-prosthetic osteolysis,
150
phosphate bioactive glasses,
206–7
physical vapour deposition,
164
physico-chemical properties,
124,
138
plasma assisted chemical vapour deposition,
127
poly(alkyl carbonate)s,
77
poly(carbonate urethane),
89,
91
poly(dichlorophosphazene),
111
poly(
ε-caprolactone),
72,
74–5
poly(ester) block copolymers,
72–5
poly(ethylene glycol),
78
poly(ethylene glycol)-fibrinogen hydrogel scaffolds,
54
poly(ferrocenyl phosphine)s,
113
poly(hydroxyurethanes),
87
polymeric ferrocenes,
113
poly(methylphenylsilane)-
b-poly(2-hydroxyethylmethacrylate),
105
poly(methylphenylsilane)-
b-poly[oligo(ethyleneglycol)methacrylate],
105
derivatives obtained via nucleophilic substitution of side chains in poly(dichlorophosphazene),
110
poly(sialate-disiloxo),
115
poly(sialate-siloxo),
114
poly(tetrahydrofurans),
87
pulsed laser deposition,
196
S
scaffold-mediated tissue remodelling,
191
selective laser sintering,
183
sequential soft machining,
180
key applications for Nitinol according to its shape memory alloy characteristics,
132
stress-strain response of Nitinol with increasing temperature,
131
silicon-based inorganic polymers,
102–9
main classes of organosilicon polymers,
102
synthesis of polysilane-poly(ethylene oxide) graft copolymer,
105
synthesis route to silicon-based polymers starting from chlorosilanes,
103
silver-based amalgam,
128
sodium alginate polymers,
47
solution-based processing,
196
spark plasma sintering,
181
synthetic inorganic polymers,
101–2
synthetic polymer biomaterials
from inorganic and mixed organic-inorganic sources,
100–16
organic-inorganic hybrid polymers,
112–14
silicon-based inorganic polymers,
102–9
synthetic inorganic polymers,
101–2