Here, we construct a quadratic spline function on the base interval 2 <= x <= 4 and compare it with the naive way of evaluating the spline:

from scipy import interpolate
import numpy as np
import matplotlib.pyplot as plt

# sampling
x = np.linspace(0, 10, 10)
y = np.sin(x)

# spline trough all the sampled points
tck = interpolate.splrep(x, y)
x2 = np.linspace(0, 10, 200)
y2 = interpolate.splev(x2, tck)

# spline with all the middle points as knots (not working yet)
# knots = x[1:-1] # it should be something like this
knots = np.array([x[1]]) # not working with above line and just seeing what this line does
weights = np.concatenate(([1],np.ones(x.shape[0]-2)*.01,[1]))
tck = interpolate.splrep(x, y, t=knots, w=weights)
x3 = np.linspace(0, 10, 200)
y3 = interpolate.splev(x2, tck)

# plot
plt.plot(x, y, 'go', x2, y2, 'b', x3, y3,'r')
plt.show()

Note that outside of the base interval, results differ. This is because BSpline extrapolates the first and last polynomial pieces of B-spline functions active on the base interval.

This is the result of solving the problem: