I am extremely grateful to Jonathan Rose and colleagues at Wiley for their assistance and considerable patience. My proposal reviewers are gratefully acknowledged for their many suggestions which helped shape this.

I would like to acknowledge my many collaborators over the years whose work in some cases has been mentioned here. In particular, Dr Joel S. Freundlich, Dr Antony J. Williams, Dr Alex M. Clark, Dr Matthew D. Krasowski, Dr Carolina H. Andrade, and many others. I am also grateful for the support of SC Johnson who have kept me challenged and engaged with new applications for computational toxicology over the years. I would also like to acknowledge Dr Daniela Schuster for the kind use of her graphic for the book cover.

This book would not have been possible without the support of Dr Maggie A.Z. Hupcey and my family who have tolerated late nights, and frequent disappearances to the library to write over the holidays.